Yes, and it’s a lengthy list. It can, however, be broken down into some broad categories of interactions.
• Combining valproic acid with other sedating medications can lead to excessive drowsiness. Care should be exercised with any painkillers containing opiates (Oxycontin, Percocet/Percodan, and Darvocet/Darvon, to name a few), benzodiazepines (the diazepam (valium) family of medications, which includes lorazepam (Ativan), clonazepam (Klonopin), alprazolam (Xanax), and others), some sedating antidepressants such as trazodone (Desyrel), over-the-counter antihistamines, sedating antipsychotics, alcohol, St. John’s Wort, and Valerian root.
• Combining valproic acid with various drugs increases the risk of bleeding. These include non-steroidal anti-inflammatory agents (NSAIDS), aspirin containing compounds, warfarin (Coumadin), willow bark, and valerian.
• Certain drugs, such as erythromycin and clarythromycin.can cause an increase in valproic acid levels. Other drugs can cause a decrease in valproic acid levels, such as lamotrigine and rifampin.
• The combination of valproic acid with lamotrigine may be associated with an increased risk of developing a serious, and potentially life-threatening, skin rash. If used in combination, patient education and close monitoring are recommended.