The San Francisco earthquake in 1906 was not the largest earthquake in U.S. history.
The strongest earthquakes recorded in U.S. history took place in a series from December 1811 to March 1812.
Occurring in the New Madrid faults in the middle of the country, the quakes changed the course of the Mississippi River, created new lakes in several states, shook two-thirds of the entire country, and were felt all the way into Canada.
Because the area was relatively uninhabited, there were no known deaths associated with these quakes.
But earthquake experts warn it will likely happen again.