The rotavirus vaccine should not be given to anyone who has had a severe allergic reaction to a previous dose of the vaccine or to any component in the vaccine. In addition, children who are moderately or severely ill should be cautioned against receiving this vaccine until they recover from their illness.
Because the vaccine contains a live, attenuated virus, it is not recommended for any person with a deficiency of the immune system. This would include anyone who has HIV or certain kinds of cancer, is receiving chemotherapy or radiation therapy, or has been on medications that suppress the immune system, such as steroids, for more than two weeks.
Although the current rotavirus vaccines have not been associated with an increased risk of intussusception, any child who has had an intussusception is at higher risk of having a repeat episode in the future. Thus, any child who has had an intussusception in the past should not receive a rotavirus vaccine.
The rotavirus vaccine is only approved for children from six weeks of age to either twenty-four or thirty two weeks of age (depending on the brand).