The Twinkies Project is a series of tests on Twinkies done by Rice University students during finals week in the 1995 school year.
What kind of tests? Subjecting Twinkies to the forces of gravity, radiation, heat, flame, and so on.
The T.W.I.N.K.I.E.S. Project, which stands for Tests With Inorganic Noxious Kakes In Extreme Situations, has a Web site with details on the experiments that walks budding scientists through Twinkies experiments of their own.